Nipah Virus Response
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Due to the recent outbreak of the Nipah virus in India, we are conducting open source research to find possible cures for the fatal infection - for which there is currently no available treatment or vaccine. We encourage researchers, scientists, and organizations to share their ideas to prevent, control and/or treat the virus.
1) Information and research regarding Nipah (disease, virus, epidemiology, drug and treatment aspects) 2) Molecular data related to Nipah (virus, toxins, drug) 3) Innovative ideas for finding solutions to prevent, control and treat the Nipah infection 4) Suggestions from credible sources, people or literature that could aid researchers |
Open Source Pharma is collaborating with institutions, laboratories, and individuals to find cures to the Nipah virus through a crowdsourcing approach. For more information and to join open projects, please visit NIPAH VIRUS OPEN RESEARCH COLLABORATIVE:
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Nipah Virus
Open Source Research and Ideas
Find the relative or similar protein and then find out the putative drug target and then respective drug.
-AMISHA SINGH (Bengaluru, India)
As normal bats are resistant to Nipah virus when infected, after infection antibodies which are produced in the bat's body can be isolated and we can prepare antidote for Nipah virus from that as from bats to bats it transfer or replicates. Normal (uninfected) bats will produce some enzymes or some changes we can identify and can isolate and work upon that.
-BHUMI MULCHANDANI
We can create an information pool for RNA polymerize inhibitors.
-SHALU MATHEW (Bangalore, India)
First knowing the main cause of disease and then going to the depth of it.
-RAHUL ANDARIA
We can prepare 'molecular imprints' of viral glycoproteins of NIPAH virus, which could be used to prevent the viruses from binding to the cellular receptors in human body. As such, these 'molecular imprints' could be used for prophylaxis and treatment of NIPAH infection.
The virus is known to spread through half eaten fruits which have been eaten by fruit bats. So basically the source of the virus is the bat. I think the research for the vaccine should start from the source itself. So the best thing to do is extract the virus from the bat and then check its interaction with the bat while also checking the same on the human host which might he infected.
-ZAHID JAWED (Lucknow, India)
Collecting information about the virus, symptoms, etc.
-MITHILNA NS (Bangalore, India)
Vaccine research and codon usage.
-REKHA MORCHHALE
As this NIPA virus is caused by Bat infection & it is also an RNA virus, if we can study the whole genome of BAT & identify the responsible mRNA which is translated by the responsible DNA. We can change some change in the DNA it self, so that the translated mRNA or viral RNA would be different & work differently.
-SUDIPTA SENGUPTA (Kolkata, India)
Find out some homologous protein which has a role in infection and validate as drug target then find the inhibitor from the already available dataset.
-SHRUTI BERIWAL (New Delhi, India)
Drug repurposing and target protein protein interaction.
-AKHIL KUMAR (Lucknow, India)
Vaccination development is the first step to protect from Nipah virus). Prevention is better than cure.
-VIJAYA. B (Nagergoil, India)
We can develop a quick easy and cheap RNA detection method based on IsoThermal amplification for Diagnostic and Surveillance.
-GUY AIDELBERG (Paris, France)
Can we prevent the infection of virus by changing blood ph?
-JADAN RESNIK (Calicut, India)
Government and NGO must take initiatives to set up Epidemic Health fund to control epidemic outbreaks.
-AFSAL KONIKKAL (Calicut, India)
Initial step is to treat those suffering with NIPAH by symptom similarity using homeopathic medicines. Secondly collect all symptoms-to form a genus epidemics. Finally use the Genus epidemics as preventive. Simultaneously follow all precautionary measures needed as is being advised. To start off conduct more medical camps to get adequate symptomatology both disease wise and patient wise to reach a definitive similimum.
-DR. VIVEK GOPALAKRISHNAN (Ernakulam, India)
I have a patented herbal formulation which is tested against Japanese Encephalitis, Rabies viruses, 'Ganjhuvir'. It is cleared FDA Karnataka for human consumption. I got a very positive response when doctors are prescribing it for some unknown cures. I am quite sure if 'Ganjhuvir' can be tried along with known potential drugs against Nipah, it can make wonders. 'Ganjhuvir' was tested in vitro in the laboratories of Manipal Centre for Virus Research, Manipal; Haffkins institute, Mumbai; NIMHANS, Bengaluru with a very positive outcome.
-RAJESH KUMAR GANJHU (Pune, India)
I believe prevention and cure should move together. Prevention should start from oneself and immediate family members through hygienic practices. I feel checking immunoglobulin levels through lab tests and improving the levels through foods and supplements (if needed) also will be a mode of prevention. Feels like how small pox was cured through vaccination, Nipah and similar infectious viral diseases could be eradicated (I have idea and list of some natural antiviral ingredients with me to experiment with and find the curative vaccine and basic knowledge of Microbiology and Medical Transcription experience of 11+ years). You may check and use the following article of mine to share with our people to create awareness about prevention. view article
-KRISHNA PRIYA (Thiruvananthapuram, India)
-AMISHA SINGH (Bengaluru, India)
As normal bats are resistant to Nipah virus when infected, after infection antibodies which are produced in the bat's body can be isolated and we can prepare antidote for Nipah virus from that as from bats to bats it transfer or replicates. Normal (uninfected) bats will produce some enzymes or some changes we can identify and can isolate and work upon that.
-BHUMI MULCHANDANI
We can create an information pool for RNA polymerize inhibitors.
-SHALU MATHEW (Bangalore, India)
First knowing the main cause of disease and then going to the depth of it.
-RAHUL ANDARIA
We can prepare 'molecular imprints' of viral glycoproteins of NIPAH virus, which could be used to prevent the viruses from binding to the cellular receptors in human body. As such, these 'molecular imprints' could be used for prophylaxis and treatment of NIPAH infection.
The virus is known to spread through half eaten fruits which have been eaten by fruit bats. So basically the source of the virus is the bat. I think the research for the vaccine should start from the source itself. So the best thing to do is extract the virus from the bat and then check its interaction with the bat while also checking the same on the human host which might he infected.
-ZAHID JAWED (Lucknow, India)
Collecting information about the virus, symptoms, etc.
-MITHILNA NS (Bangalore, India)
Vaccine research and codon usage.
-REKHA MORCHHALE
As this NIPA virus is caused by Bat infection & it is also an RNA virus, if we can study the whole genome of BAT & identify the responsible mRNA which is translated by the responsible DNA. We can change some change in the DNA it self, so that the translated mRNA or viral RNA would be different & work differently.
-SUDIPTA SENGUPTA (Kolkata, India)
Find out some homologous protein which has a role in infection and validate as drug target then find the inhibitor from the already available dataset.
-SHRUTI BERIWAL (New Delhi, India)
Drug repurposing and target protein protein interaction.
-AKHIL KUMAR (Lucknow, India)
Vaccination development is the first step to protect from Nipah virus). Prevention is better than cure.
-VIJAYA. B (Nagergoil, India)
We can develop a quick easy and cheap RNA detection method based on IsoThermal amplification for Diagnostic and Surveillance.
-GUY AIDELBERG (Paris, France)
Can we prevent the infection of virus by changing blood ph?
-JADAN RESNIK (Calicut, India)
Government and NGO must take initiatives to set up Epidemic Health fund to control epidemic outbreaks.
-AFSAL KONIKKAL (Calicut, India)
Initial step is to treat those suffering with NIPAH by symptom similarity using homeopathic medicines. Secondly collect all symptoms-to form a genus epidemics. Finally use the Genus epidemics as preventive. Simultaneously follow all precautionary measures needed as is being advised. To start off conduct more medical camps to get adequate symptomatology both disease wise and patient wise to reach a definitive similimum.
-DR. VIVEK GOPALAKRISHNAN (Ernakulam, India)
I have a patented herbal formulation which is tested against Japanese Encephalitis, Rabies viruses, 'Ganjhuvir'. It is cleared FDA Karnataka for human consumption. I got a very positive response when doctors are prescribing it for some unknown cures. I am quite sure if 'Ganjhuvir' can be tried along with known potential drugs against Nipah, it can make wonders. 'Ganjhuvir' was tested in vitro in the laboratories of Manipal Centre for Virus Research, Manipal; Haffkins institute, Mumbai; NIMHANS, Bengaluru with a very positive outcome.
-RAJESH KUMAR GANJHU (Pune, India)
I believe prevention and cure should move together. Prevention should start from oneself and immediate family members through hygienic practices. I feel checking immunoglobulin levels through lab tests and improving the levels through foods and supplements (if needed) also will be a mode of prevention. Feels like how small pox was cured through vaccination, Nipah and similar infectious viral diseases could be eradicated (I have idea and list of some natural antiviral ingredients with me to experiment with and find the curative vaccine and basic knowledge of Microbiology and Medical Transcription experience of 11+ years). You may check and use the following article of mine to share with our people to create awareness about prevention. view article
-KRISHNA PRIYA (Thiruvananthapuram, India)
