PROJECTS

Clinical Trials

India Health Fund​ Open Source Clinical Trial 
Repurposing already-approved “off patent generic drugs” in order to rapidly and cost-effectively create new treatments and regimens against neglected infectious diseases, using open methodology conforming to standard regulatory endpoints.  Future project. Funded by the India Health Fund.

Metformin Clinical Trial​​ 
​A 3-center Phase 2b clinical trial of metformin, a generic diabetes drug, as an adjunct therapy for tuberculosis. Open IP, open data (once ready), and openly-available protocol published in open access academic journal. In partnership with the Government of India’s National Institute for Research in Tuberculosis (NIRT). CTRI site | More about the trial | Join the OSP Metformin-TB Facebook page

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Early Stage Drug Discovery

Ayurvedic Research​​ 
​Accumulating and analyzing traditional health care systems with modern tools.

Crowdsource Program for Neglected Disease Research 
An evolving project and discussion space for post graduates, researchers, and professional students who are passionate about solving problems in the health sector, particularly with a focus on neglected diseases

Generics Repurposing Database Project
​Enabling low cost generic drugs to be used for other diseases on an affordable basis.

In Silico Research 
Peer-reviewed research papers have been published by members of the OSPF Bangalore scientific team and affiliated open researchers. View publications

Nipah Virus Response 
Conducting open source research to find possible cures for the fatal infection - for which there is currently no available treatment or vaccine. ​Learn more

TB, Chikungunya, and Nipah Virus Knowledge Graph 
Building an open, living, AI-powered, automatically updated knowledge base and knowledge graph focused on the specific content needed to enable drug discovery and development for TB, Chikungunya, and Nipah Virus. US operations funded by Wellcome Trust, UK. TB Knowledge Graph in partnership with Mayo Clinic Center for Tuberculosis. OSPF has partnered with Ingentium, Inc., to provide interactive knowledgebases and knowledgegraphs for TB, Chikungunya, and Nipah Virus. An interactive dashboard which provides easy access to all tools and applications is available.

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Education and Awareness

Global Conferences

• ​The 3rd Open Source Pharma Conference (OSP3), held in Paris in March 2019, at CRI Research, was a gathering of researchers, entrepreneurs, industry professionals, funders and NGOs who aim to achieve radical improvements in the way therapeutics are delivered to market in the 21st century. This meeting followed the 1st OSP conference, which took place at the Bellagio Center, Lake Como, Italy in 2014, and the second, which took place at Castle Rauischholzhausen, Marburg, Germany in 2015. See past conferences
• The 50th Union World Conference on Lung Health, held in Hyderabad, India from October 30-November 2, 2019 on the theme Ending the Emergency: Science, Leadership, Action. This meeting is the world’s largest gathering of clinicians and public health workers, health programme managers, policymakers, researchers and advocates working to end the suffering caused by lung disease, including tuberculosis. View site

TB Digital Quilt 
​A collection of videos, displayed in the form of a quilt, contributed by people across the world sharing their thoughts and experiences concerning tuberculosis to raise awareness about TB and bring together community in support of those affected by the disease. www.tbdigitalquilt.org

Lectures, Meetings, Workshops​

• Public Lecture by Christopher P. Austin (Director, NCATS/NIH - August 5, 2020 - via Zoom) - "Drug Repurposing: Opportunities, Challenges, and Conceptualization of a Research Agenda". Watch Webinar
• Harvard Global Health Institute Dinner (March 21, 2020 - via Zoom) - A meeting to explore the topic of open-source approaches to pharma R&D. Learn more
• Harvard Global Health Institute Dinner (December 3, 2019) - An engaging and lively discussion on open source pharma for neglected diseases. ​View invitation
• World TB Day 2018 at NIAS (March 24, 2018) - An event organized by OSPF students gathering over 40 interns, researchers, scientists, and thought leaders that included activities, workshops, as well as presentations
• ​Public Lecture at NIAS by Jaykumar Menon (Co-founder, Open Source Pharma Foundation - January 12, 2018) - "Open Source Model for Affordable Health Care and Wellbeing". View poster
• Access to Research Workshop (August 11, 2018) - A workshop to train clinical practitioners from various disciplines and help them gain access to research to identify problems, contribute their scientific knowledge, and support the drug discovery ecosystem
• Public Lecture at NIAS by Adrian Bradley (UK and European Patent Attorney, Cleveland Scott York) - “Intellectual Property as a Mechanism for Translating Research into Societal Benefits”

Women Scientists Program 
​A series of workshops connecting women scientists through virtual labs and whittling down potential molecules that could eventually be turned into drugs to fight diseases, such as tuberculosis. View BBC News article 

In partnership with the National Institute for Research in Tuberculosis in India, we have commenced a multicentric phase 2b clinical trial

Learn More

World TB Day 2018, NIAS, Bangalore