Below is a list of projects applying open source principles to R&D for the COVID-19 crisis. Learn more about each initiative and contribute to the effort. Together, we seek to address the pandemic and leverage collaborative approaches.
LIST OF PROJECTS
Open Source COVID-19 Vaccine
Humanity’s urgent need for a vaccine, or set of vaccines, for SARS-CoV-2 needs no elaboration. Quite simply, this is one of the more pressing scientific/humanitarian needs of the century.
There is an enormous amount of ongoing work in the public, private, and nonprofit sectors. The bulk of it, however, is along business-as-usual lines, with heavy competition among companies, even nations. (See “Search for Coronavirus Vaccine Becomes a Global Competition,” NY Times, March 19, 2020).
In open source software, not only are the incoming and outgoing results widely usable, but the very process of development itself, the actual daily work, is open, collaborative, global. The magic of this collaboration created, for example, Linux, which dominates the supercomputer market, and the LAMP stack, which birthed the World Wide Web. Can we learn from these principles, and apply them to the process of vaccine R&D?
If we were really serious about developing a vaccine, we would not work through single labs, or even consortia. Rather, we would have the entire world look at the problem at once.
Project partner, European Vaccine Initiative.
Open Source COVID-19 Drugs: In Silico Drug Repurposing
This crowdsourcing for open source COVID-19 drug repurposing research project can be broken down into the following steps:
A. Crowdsource to build a systems biology model for the virus, and for drug target identification.
B. Virus target on host receptor (ACE2) modeling.
C. Host factors that can protect from the virus.
Project conceptualized by and mentored by Professor Samir K. Brahmachari.
OSP Idea Factory: C-19 Drug Discovery Hypotheses
This is a Massive Online Open Research (MOOR) initiative for COVID-19, a global collaborative research effort of the open source pharma community that seeks to tap into the minds of scientists and researchers across the world to virtually screen molecules to fight the virus. Through collective intelligence and open source approaches, we can support the rapid discovery of molecules and COVID-19 targets. Phase 1 of this project involves docking various molecules in the targets of COVID-19. We welcome all to contribute their hypotheses using the form below.
Global Repurposing Platform COVID-19
The outbreak of COVID-19, a new strain of coronavirus, emerged from Wuhan in late 2019, China and has spread globally ever since its outbreak. Currently, there is no definite treatment for COVID-19, although few therapeutics, such as small molecules, vaccines, antibodies are under investigation. The need of the hour is to come up with a treatment at the earliest possible. So our strategy is to look into FDA approved drugs that could be repurposed against COVID-19.
Towards this endeavour we are making a consolidated effort to bring on to the platform different resources available globally for repurposing FDA approved drugs for COVID. We will plug in a discussion forum on top of it, which would enable the participation of scientific/non-scientific communities from different parts of the globe.
Crowdsourced Face Masks
In collaboration with its community and professional networks, the Open Source Pharma Foundation (OSPF) is exploring the production and distribution of face masks to fight the spread of COVID-19. Through crowdsourcing thoughts, open source designs, and ideas from the public, we aim to help the effort to create low-cost and effective masks on a large-scale.
If you have a project to suggest, please get in touch with firstname.lastname@example.org